The Italian physician and naturalist Andrea Bacci (1524-1600) from Sant'Elpidio a Mare in the region today Brands studied medicine in Siena and Rome, where he was promoted by Modestino Cassini, the personal physician of Emperor Maximilian II (1527-1576). Later Bacci became the personal physician of Pope Sixtus V. (1521-1590). He especially recommended the wines Liguria from z. B. the variety Rossese to whom he attributed magical powers, saying "that they could even make stones bloom" . He taught botany and pharmacology in Rome and wrote numerous pharmacological and toxicological writings. In his natural history work "De Naturalis Vinorum Historia" he described the Italian wines from many regions. From his native Marche he reports that the Carthaginian general Hannibal (247-183 BC) in the train against Rome, the dull horses of his army with the tasting of a large amount of Conero (today DOC Rosso Conero ) healed. He also praises the excellent wines Abruzzo and labeled Sardinia as "island of wines".
One already by the Greek historian Strabo (63 BC to 28 AD) mentioned wine from the village Cirella (today's region Calabria ) he praises with exuberant words. "In the village of Cirella, not far from the Lao River, two types of wine are made bright and red. The first variety, called Cirella wine, has taken the name Chiaretto (rosé wine) because of its luster and body, and because it could compete with gold for clarity. Among the other wines he has the privilege of holding himself for two or three years, and he deserves to be called the unique example of a more exquisite wine; It is therefore considered commonplace on public tables and among the innkeepers. It is extremely pleasant for the palate and stomach, slips quickly into the first veins and into the kidneys, it is very nutritious, produces good and thin blood, guides the remains of the Body juices in their natural pathways, is sweaty and urintreibend, and sells kidney semolina. It does not rise to the head, but rather enlivens all the senses, and miraculously drives the mind of the ancients and those who are drowsy in the mind to much profound speculation. He amuses heart and soul. "