Italian doctor and naturalist Andrea Bacci (1524-1600) from Sant'Elpidio a Mare in today's region Brands studied medicine in Siena and Rome, where he was promoted by Modestino Cassini, the personal physician of Emperor Maximilian II (1527-1576). Bacci later became the personal physician of Pope Sixtus V (1521-1590). He particularly recommended the wines to him Liguria from z. B. the variety Rossese, whom he believed to have magical powers and said "that these could even make stones bloom" . He taught botany and pharmaceutical science in Rome and wrote numerous pharmacological and toxicological writings. In his natural history main work "De Naturalis Vinorum Historia" he described the Italian wines from many regions. He reports from his homeland of brands that the Carthaginian general Hannibal (247-183 BC) pulled the dull horses of his army with a large amount of Conero (today DOC Rosso Conero ) healed. He also commends the excellent wines Abruzzo and labeled Sardinia as the "island of wines".
One already by the Greek historian Strabo (63 BC to AD 28) mentioned wine from the village of Cirella (today's region Calabria ) he praises with exuberant words. “In the village of Cirella, not far from the Lao River, two types of wine are produced in light and red. The first variety, called Cirella Wine, adopted the name Chiaretto (rosé wine) because of its luster and body, and because it could compete with gold for clarity. Among the other wines, it has the advantage of lasting two or three years, and it deserves to be called the unique example of a more exquisite wine; It is therefore regarded as common on common tables and among innkeepers, is extremely pleasant for the palate and stomach, quickly slips into the first veins and down to the kidneys, it is very nutritious, produces good and thin blood, carries the remains of Body juices in their natural pathways, are sweat and urine-driving, and expel kidney semolina. It does not rise to the head, but rather invigorates all the senses and miraculously drives the spirit of the old and the sleepy in the spirit to deep speculation. It cheers up heart and soul. "