The winery is located in the municipality Moulis (Moulis-en-Médoc) around the area of the same name in the Médoc (Haut-Médoc, Bordeaux). In the Bordeaux Classification according to the old system, which is no longer valid, it was last classified as "Cru Bourgeois Exceptionnel" in 2003. Until the beginning of the 19th century, the Gressier family owned vineyards called Grand-Poujeaux. The extensive property was acquired by the dealer André Castaing in 1806. In 1820 there was a first division of inheritance, from which subsequently Château Gressier Grand-Poujeaux. Château Maucaillou and Château Poujeaux emerged.
Another part of the inheritance consisted of a part that was then nameless. When it was divided again in 1860, a name had to be found. This was allegedly based on a quote from the famous English poet Lord Byron (1788-1824). During a visit to Bordeaux, the very melancholy artist became acquainted with the Moulis wine, suddenly felt better and single of all his worries after enjoying it and coined the term "getting rid of the blues" (French: "chasser le spleen", analogously "scare away bad mood"). Another version attributes the origin of the name to the French writer Charles-Pierre Baudelaire (1821-1867), who was on vacation nearby. One of the themes of his famous volume of poems "Les Fleurs du Mal" was called "Spleen et Ideal".
After the end of the Castaing era in 1909, there were several changes of ownership and through phylloxera, World War II and economic problems to decline. In the mid-1970s, the estate was managed by the Taillan Group under the direction of Jacques Merlaut (+2008) acquired. His daughter Bernadette Villars succeeded in the resuscitation, after her tragic death it has been managed by her daughter Claire Villars-Lurton since 1992. The vineyards cover 72 hectares and are part of Cabernet Sauvignon (50%), Merlot (45%), Petit Verdot (3%) and Cabernet Franc (2%) planted. The long-lived red wine matures in 24% new barriques for up to 24 months. The second wines are called "L'Ermitage de Chasse-Spleen" and "L'Oratoire de Chasse-Spleen".