The winery is located in the municipality Moulis (Moulis-en-Médoc) around the eponymous area in the Médoc (Haut-Médoc, Bordeaux). In the Bordeaux Classification according to the old now no longer valid system, it was last classified in 2003 as "Cru Bourgeois Exceptionnel". Until the beginning of the 19th century, the Gressier family owned vineyards called Grand-Poujeaux. The extensive property was acquired in 1806 by the merchant André Castaing. In 1820 there was a first inheritance, from which in the episode Château Gressier Grand-Poujeaux. Château Maucaillou and Château Poujeaux emerged.
Another inheritance consisted of a then nameless part. When this was again divided in 1860, a name had to be found. Supposedly, this resulted from a quote by the famous English poet Lord Byron (1788-1824). On a visit to Bordeaux, the very melancholy artist made the acquaintance of the Moulis wine, felt after drinking suddenly better and unaware of all his worries and coined the term "getting rid of the blues" (French "chasser le spleen"). mutatis mutandis "scare bad mood"). Another version, however, attributes the origin of the name to the French writer Charles-Pierre Baudelaire (1821-1867), who was nearby on leave. One of the themes of his famous book of poetry "Les Fleurs du Mal" was called "Spleen et Ideal".
After the end of the Castaing era in 1909, there were several changes of ownership and by phylloxera, World War II and economic problems to decline. Mid-1970s, the estate was from the Taillan Group under the direction of Jacques Merlaut (+2008) acquired. His daughter Bernadette Villars managed the successful revival, after its tragic death, it is directed since 1992 by her daughter Claire Villars -Lurton. The vineyards cover 72 hectares and are with Cabernet Sauvignon (50%), Merlot (45%), Petit Verdot (3%) and Cabernet Franc (2%). The long-lived red wine matures for up to 24 months in 50% new oak barrels. The second wines are called "L'Ermitage de Chasse-Spleen" and "L'Oratoire de Chasse-Spleen".