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The Greek physician Hippocrates (460-377 BC) was on the island of Kos in the eastern Aegean born and is called the father of medicine. The "Hippocratic Oath" still defines the moral and ethical duties of the physician today. Wine plays an important role in almost all of the traditional medicines. In his work "Corpus Hippocraticum" is in the form of therapeutic recommendations on the health Aspects of wine consumption pointed out by numerous examples. He prescribed wine among other things to cool the fever, as a general germicide, as a diuretic and as a fortifying for convalescents. Hippocrates gave detailed information and recommended according to the suffering of certain wines or even advised against the enjoyment at all.

He also had very specific ideas on how to drink wine, neither too cold nor too warm. Prolonged enjoyment of warm wine, he claimed, would lead to imbecility, while excessive consumption of cold wine would lead to convulsions, cramps, burning, chills and fever. It was above all the Roman general Julius Caesar (100-44 BC), who used this knowledge in his subsequent campaigns in the following years. His legionaries received a daily ration of wine to help prevent bowel disease. Hippocrates recognized the chemical processes in the human body in the context of wine:

"Wine is a thing wonderfully suited to man, provided that the drink is used reasonably and in the right amount in good and bad health, consistent with the physical condition of the individual. Mild, dark wines are wetter, have a flatulent and go better with the chair. Heat white white wines without drying them out, and they'll do better with the urine than with the chair. New wines go better with the chair than others, because they are closer to the must and therefore more nutritious. Most causes winds, stirs up the intestines and empties them. Sweet, partially fermented wine causes less heaviness in the head than vinoser (heavily fermented with more alcohol content), he goes less into the brain, empties the intestines more than that, but causes the spleen and the liver to swell. However, if there is a suspicion of an excessive heaviness of the head or an indication that the brain is affected, the wine must be sharply discouraged " .

According to the doctor are the "sleeve of Hippocrates", a filter bag used until the Middle Ages, as well as the spiced wine Hypocras named. In the second century after Christ there was a true Hippocrates renaissance, including the Greek doctor Galenos of Pergamon (129-216) contributed.

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