The Italian noble family de 'Medici (Medici) from Florence had their origins in merchants and bankers. She advanced from a wealthy but insignificant family to one of the most influential Italian dynasties of the 15th and 16th centuries, through skillful tactics and brutal intrigues. Florence became under the Medici center of medieval European commerce and finance and one of the most prosperous cities of that time. It is considered the cradle of the Renaissance. Inextricably linked to the Tuscan history, the family promoted art, science and viticulture. Lorenzo I (1449-1492), known as "El Magnifico" (the Magnificent), is regarded as the founder of the ruling dynasty. He led the city to the highest economic and cultural flowering. From the beginning of the 16th century, the Tuscany united and in 1569 under Cosimo III. (1642-1723) raised by Pope Pius V (1504-1572) to the Grand Duchy.
Giovanni de 'Medici (1475-1521) was Leo X., the first pope of the family, followed by his cousin Giulio as Clement VII (1523-1534). His nephew Alessandro Ottaviano de'Medici (1535-1605) ruled as Pope Leo XI. only for a few weeks; with him the "older line" died out. The "younger line" was founded by Duke Cosimo I (1519-1574). The already mentioned grandson Grand Duke Cosimo III. introduced 150 grape varieties in Tuscany, including Uva Francesca ( Cabernet Sauvignon ). According to another version, the variety should have been imported much earlier by Caterina de 'Medici (1519-1589), known above all for the notorious "Bartholomew's Night". That was the year in which, at the age of 14, she married the future King Henry II and became Queen of France. Under Cosimo III. In 1716, the boundaries were set for the wine-growing areas Carmignano. Chianti (then the part Chianti Classico ) Pomino and Val d'Arno di Sopra, these are therefore among the oldest official Origin designations Europe.