The Italian noble family de 'Medici (Mediceer) from Florence had their origins in merchants and bankers. Through clever tactics and brutal intrigue, she rose from a wealthy but insignificant family to one of the most influential Italian dynasties of the 15th and 16th centuries. Florence became among the Medici center of medieval European trade and finance and one of the most prosperous cities of that time. It is considered the cradle of the Renaissance. Inextricably linked to Tuscan history, the family promoted art, science and viticulture. The founder of the ruling dynasty is Lorenzo I (1449-1492), known as "El Magnifico" (the magnificent). He led the city to its greatest economic and cultural boom. From the beginning of the 16th century, the Tuscany united and in 1569 under Cosimo III. (1642-1723) raised by Pope Pius V (1504-1572) to the Grand Duchy.
Giovanni de 'Medici (1475-1521), as Leo X, became the first pope in the family to be succeeded by his cousin Giulio as Clement VII (1523–1534). His nephew Alessandro Ottaviano de´ Medici (1535-1605) ruled as Pope Leo XI. only for a few weeks; with him the "older line" died out. The "younger line" was founded by Duke Cosimo I (1519-1574). The already mentioned grandson Grand Duke Cosimo III. introduced 150 grape varieties in Tuscany, including Uva Francesca ( Cabernet Sauvignon ). According to another version, the variety is said to have been imported much earlier by Caterina de 'Medici (1519-1589), who is best known for the notorious “Bartholomew Night”. That was the year in which, when she was 14, she later married Queen Henry II and became Queen of France. Under Cosimo III. In 1716, the boundaries for the viticultural areas Carmignano. Chianti (then the part Chianti Classico ) Pomino and Val d'Arno di Sopra, which make them one of the oldest official Origin designations Europe.