Under mutations (from Latin mutare "change, transform") one understands spontaneously in the nature occurring changes of the genetic information in the genome of the cell nuclei of plant and animal organisms, which play an important role in the evolution. These usually occur selectively (point mutations), but can also be larger DNA segments include (deletion, insertion, chromosome breaks). If the mutations in the germ line are successful, they are passed on to the next generation. If the organism is not cloned or propagated by reproduction, the mutations accumulated in cell nuclei with age disappear with the natural death of the organism. Only a small percentage of spontaneous mutations produce positive effects, many mutations remain silent or express minimal or gradual. Since the end of the 20th century, mutations have also been artificially induced by gene manipulation.